Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity
نویسندگان
چکیده
منابع مشابه
Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity
Cyclooxygenases and lipoxygenases are proinflammatory enzymes; the former affects platelet aggregation, vasoconstriction, vasodilatation and later the development of atherosclerosis. Red wines from Georgia and central and western Europe inhibited cyclooxygenase-1 (COX-1) activity in the range of 63-94%, cyclooxygenase-2 (COX-2) activity in the range of 20-44% (tested at a concentration of 5 mL/...
متن کاملImpact of Aspirin Eugenol Ester on Cyclooxygenase-1，Cyclooxygenase-2，C-reactive protein，Prothrombin and Arachidonate 5-lipoxygenase in Healthy Rats
Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...
متن کاملImpact of Aspirin Eugenol Ester on Cyclooxygenase-1，Cyclooxygenase-2，C-reactive protein，Prothrombin and Arachidonate 5-lipoxygenase in Healthy Rats
Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...
متن کاملCyclooxygenase‐2 and 5‐Lipoxygenase in Dogs with Chronic Enteropathies
BACKGROUND Cyclooxygenase-2 (COX-2) is a key enzyme in the synthesis of pro-inflammatory prostaglandins and 5-lipoxygenase (5-LO) is the major source of leukotrienes. Their role in IBD has been demonstrated in humans and animal models, but not in dogs with chronic enteropathies (CCE). HYPOTHESIS COX-2 and 5-LO are upregulated in dogs with CCE. ANIMALS Fifteen healthy control dogs (HCD), 10 ...
متن کاملThe expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
OBJECTIVE To describe cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) expression in muscle tissue in patients with idiopathic inflammatory myopathies (IIM) - dermatomyositis (DM) and polymyositis (PM) and to find out if any differences between affected and non-affected muscles detected by MRI exist. METHODS Samples of muscle tissue from 7 patients with dermatomyo...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2014
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2014/178931